What nobody tells you about GLP-1s.

25 to 40% of the weight you lose on Ozempic, Wegovy, Mounjaro, or Zepbound is muscle. Unless you do two specific things. This is the guide I want every patient to read before they start.

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    Sean Hashmi, MD

    Nephrologist · Obesity Medicine Founder, SELFPrinciple.org

    Who am I?

    Dr. Sean Hashmi is a board-certified nephrologist and obesity medicine specialist who founded SELFPrinciple.org, a 501(c)(3) nonprofit translating peer-reviewed research into clear, actionable health guidance. His work reaches patients on YouTube, Instagram, and the SELF Principle podcast. Every recommendation in this guide is anchored in current evidence, FDA labels, and the major GLP-1 trials (STEP, SURMOUNT, SELECT, FLOW).

    What will you learn?

    • The muscle loss math nobody is showing you
    • The two interventions that protect lean mass
    • The six FDA-approved GLP-1s and what they actually do
    • Cost, coverage, and how to win the insurance appeal
    • The questions to ask before the prescription is written
    • What happens when you stop, and how to plan the exit